May 2022

With technical input from Andrew Thresher. Would your toxicology assessments benefit from free access to long-term carcinogenicity study data? The Lhasa Carcinogenicity Database (LCDB) is a widely used, free resource of long-term carcinogenicity study data. In this article we explore 5 things you should know about the data in the LCDB. 1. The Lhasa Carcinogenicity […]

When assessing the mutagenic potential of drug impurities in silico, the ICH M7 guideline states that two complementary (Q)SAR prediction methodologies should be applied. A provision for the application of ‘expert knowledge’ is also mentioned within the guideline. However, as (Q)SAR models continue to be updated and their predictive performance and structural coverage improves, this raises